The underlying pathophysiology of bronchiectasis has been described in the literature as a “vicious cycle” or “vicious vortex” consisting of four interconnected components: impaired mucociliary clearance, chronic infection, chronic inflammation, which is primarily neutrophilic, and lung destruction.1,2 Find out how these four drivers of bronchiectasis contribute to disease progression in this quick video.
References:
- Flume PA, Chalmers JD, Olivier KN. Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity. Lancet. 2018;392(10150):880–890.
- Metersky ML, Barker AF. The pathogenesis of bronchiectasis. Clin Chest Med. 2022;43(1):35–46.
© 2024 Insmed Incorporated. All Rights Reserved.
NP-BE-US-00632 09/24
